CAR-T cell therapy has achieved groundbreaking success in the treatment of hematologic malignancies, but its efficacy in solid tumors has been limited. Solid tumors are known to possess high tumor heterogeneity and an immunosuppressive tumor microenvironment that hinders CAR-T cell function. Therefore, inducing immunogenic cell death to convert a cold tumor into a hot tumor, and promoting antigen spreading to prime diverse T cells, can be a key strategy to overcome solid tumors. In this poster, we demonstrate that cancer cells undergoing pyroptosis, rather than conventional apoptotic cell death, can directly enhance the proliferation and function of CAR-T cells. These findings suggest the potential for developing combination therapies involving CAR-T cells and agents that induce immunogenic cell death.